Malabaricone C from Myristica cinnamomea exhibits anti-quorum sensing activity.

نویسندگان

  • Yee Meng Chong
  • Wai Fong Yin
  • Chia Yong Ho
  • Mohamad Rais Mustafa
  • A Hamid A Hadi
  • Khalijah Awang
  • Putri Narrima
  • Chong-Lek Koh
  • David R Appleton
  • Kok-Gan Chan
چکیده

A methanol-soluble extract of the bark of Myristica cinnamomea was found to exhibit anti-quorum sensing activity, and subsequent bioassay-guided isolation led to the identification of the active compound malabaricone C (1). Compound 1 inhibited violacein production by Chromobacterium violaceum CV026 when grown in the presence of a cognate signaling molecule, N-3-oxohexanoyl-homoserine lactone. Furthermore, 1 inhibited the quorum sensing-regulated pyocyanin production and biofilm formation in Pseudomonas aeruginosa PAO1. These results suggest that the anti-quorum sensing activity of 1 and related molecules should be investigated further.

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عنوان ژورنال:
  • Journal of natural products

دوره 74 10  شماره 

صفحات  -

تاریخ انتشار 2011